报告题目：Empowering Organic Synthesis:From Unique Methods to Complex Natural Products

报告时间：2024年10月18日（周五）17:00

报告地点：电化学楼C512会议室

报告人简介：David Sarlah was born and raised in Slovenia, where he obtained his Bachelor’s Degree in Chemistry at the University of Ljubljana. He carried out his undergraduate research with Prof. K. C. Nicolaou at Scripps and Prof. Samuel J. Danishefsky at Columbia. He obtained his Ph.D. in chemistry with Prof. K. C. Nicolaou involving the total synthesis of complex natural products. David then joined Prof. Erick M. Carreira's group at ETH as a postdoctoral fellow and explored the field of asymmetric catalysis. In 2014, David joined the faculty at the University of Illinois, Urbana-Champaign, and moved to Rice University in 2024. His research interests span from the synthesis of complex, biologically active natural products and the related chemical biology to methodology development.

报告简介：Our group is developing new methodologies and strategies that enable rapid and selective construction of molecular complexity. This lecture will cover three recent and ongoing topics related to pursuing such goals. First, the synthesis of complex bis-macrocyclic peptide darobactin A will be presented, highlighting the use of halogen-selective Larock indolization, which was needed for achieving the desired atroposelectivity. Next, a unique,catalyst-controlled stereodivergent cycloisomerization strategy will be disclosed that delivers access to all possible perhydrobenz[e]indene terpenoids. Finally, a dearomative methodology involving arenophiles provided selective access to several complex aminoglycoside antibiotics.