报告题目：Lifting the Synergies of Super-Resolution Microscopy and DNA Nanotechnology

报告人：Philip Tinnefeld教授，Ludwig-Maximilians-Universität München

报告时间：2025年9月8日（周一）10：00

报告地点：电化学楼C512会议室

报告人简介：Philip Tinnefeld is director of the chemistry department and chair of physical chemistry at LMU Munich. He leads an interdisciplinary research group in single-molecule spectroscopy, super-resolution microscopy, DNA nanotechnology and biosensing with a focus on method development. He has contributed to breakthroughs in super-resolution microscopy with the techniques dSTORM, DNA-PAINT and pMINFLUX. Recently, he combined single-molecule detection with DNA nanotechnology to develop self-assembled functional devices, biosensors and nano-robots. In addition to more than 200 peer-reviewed publications, he is involved in 10 patent applications and is initiator of GATTAquant, the first company for DNA origami applications.

报告简介：DNA origami enables the bottom-up design of molecular devices and nanorobots, whose functions we visualize using optical single-molecule techniques. Conversely, DNA nanotechnology advances super-resolution microscopy by providing transient, orthogonal interactions exploited in DNA-PAINT. In this presentation, I will highlight recent breakthroughs, including sub-nanometer–precise visualization of DNA-protein interactions using pulse-interleaved MINFLUX and graphene energy transfer with vertical DNA (Nat Methods, 2025; Nature Photonics, 2024). I will also showcase applications of DNA nanotechnology in constructing complex sensors and fluorescence amplifiers, enabling single-molecule detection even on portable smartphone microscopes (Adv Mater, 2025, Nat Nanotechnol, 2025). Finally, I will discuss how autonomous DNA machines can be powered, and how their energy consumption can be minimized through Brownian DNA computation.