个人简介

武汉大学化学与分子科学学院副教授，博士生导师。多年来专注于小分子及纳米荧光探针的设计合成、细胞及动植物组织荧光成像、高效液相色谱/毛细管电泳等方面的科研工作。截止目前，申请者已主持国家自然科学基金面上项目1项，青年项目1项，湖北省自然科学基金面上项目1项，江苏省自然科学基金青年项目1项，横向课题多项，参与国家自然科学基金重点项目1项，面上项目多项，在国内外发表学术论文60余篇。

教育经历

2000.09-2004.06    武汉大学化学与分子科学学院   大学本科

2004.09-2009.06    武汉大学化学与分子科学学院   博士研究生

工作经历

2009.07-2016.09    武汉大学化学与分子科学学院   讲师

2014.09-2015.08    美国圣母大学化学与生物化学学院   访问学者

2016.10-至今         武汉大学化学与分子科学学院   副教授

研究方向

荧光探针设计合成、生物成像、高效液相色谱/毛细管电泳

代表成果

1. S. He, W. Fang, X. Guo, H. Wang, A water-soluble two-photon fluorescent probe for rapid and reversible monitoring of redox state, Talanta, 2023, 253: 124066.

2. N. Wei, Y. Sun, X. Guo, H. Wang, Synthesis of sulfhydryl functionalized silicon quantum dots with high quantum yield for imaging of hypochlorite in cells and zebrafish, Microchimica Acta, 2022, 189: 329.

3. Y. Sun, L. Pang, X. Guo, H. Wang, Synthesis of metal ion tolerant Mn-doped fluorescence silicon quantum dots with green emission and its application for selective imaging of ·OH in living cells, Microchimica Acta, 2022, 189:

4. M. Fu, N. Wei, L. Pang, X. Guo, H. Wang, Red emission nitrogen and zinc co-doped carbon dots as fluorescent sensor for reversible detection of peroxynitrite in living cells, Sensors and Actuators B: Chemical, 2022, 351: 130939.

5. Y.J. Tang, S. He, X.F. Guo, H. Wang, A redox reversible endoplasmic reticulum-targeted fluorescent probe for revealing  the redox status of living cells, Analyst, 2021, 146: 7740.

6. L. Pang, Y. Sun, X. Guo, H. Wang, Cell membrane-targeted near-infrared carbon dots for imaging of hydrogen sulfide released through the cell membrane, Sensors and Actuators B: Chemical, 2021, 345: 130403.

7. Y.J. Tang, W.L. Fang, K. Ren, X.F. Guo, H. Wang, A turn-on homodimer fluorescent probe based on homo-FRET for the sensing of biothiols in lysosome: a trial of a new turn-on strategy, Analyst, 2021, 146: 2974.

8. H. Wu, L. Pang, N. Wei, X. Guo, H. Wang, Nucleus-targeted N-doped carbon dots via DNA-binding for imaging of hypochlorous in cells and zebrafish, Sensors and Actuators B: Chemical, 2021, 333: 129626.

9. N. Wei, M. Wei, B. Huang, X. Guo, H. Wang, One-pot facile synthesis of green-emitting fluorescent silicon quantum dots for the highly selective and sensitive detection of nitrite in food samples, Dyes and Pigments, 2021, 184: 108848.

10. H. Yao, X. Guo, H. Wang, Simultaneous Quantitation of Intra- and Extracellular Nitric Oxide in Single Macrophage RAW 264.7 Cells by Capillary Electrophoresis with Laser-Induced Fluorescence Detection, Analytical Chemistry, 2020, 92: 11904.