个人简介
田沺，教授、博士生导师、国家优青获得者、武汉大学珞珈青年学者
教育经历
2000.09-2004.06 武汉大学化学与分子科学学院 大学本科 导师：万婕教授
2004.09-2009.06 武汉大学化学与分子科学学院 博士研究生 导师：周翔教授
2010.05-2012.05 武汉大学生命科学学院 博士后 合作导师：吴建国教授
工作经历
2012.11-2015.10 武汉大学化学与分子科学学院 副教授
2015.11-至今 武汉大学化学与分子科学学院 教授
研究方向
主要科研工作围绕核酸化学生物学开展工作，主要针对特殊二级结构核酸(G-四链核酸、左手螺旋核酸Z-DNA)以及修饰核酸，进行结构与功能研究；发展小分子探针策略，对核酸的结构和功能进行调控；进一步拓展以特殊二级结构核酸为靶标的创新药物设计和调控工具系统；重点解决传统方向以外的新功能揭示以及创新应用拓展。
代表成果
1. Shaoru Wang#, Lingyu Wu#, Haiyan Huang#, Wei Xiong, Jian Liu, Lai Wei, Ping Yin, Tian Tian*, Xiang Zhou*. Conditional control of RNA-guided nucleic acid cleavage and gene editing. Nature Communications, 2020, 11, 91.
2. Shaoru Wang#, Haiyan Huang#, Jian Liu, Lai Wei, Lingyu Wu, Wei Xiong, Ping Yin, Tian Tian*, Xiang Zhou*. The manipulation of RNA-guided nucleic acid cleavage with ninhydrin chemistry. Advanced Science, 2020, 11, 1903770.
3.Wang, S. R.#; Min, Y. Q.#; Wang, J. Q.; Liu, C. X.; Fu, B. S.; Wu, F.; Wu, L. Y.; Qiao, Z. X.; Song, Y. Y.; Xu, G. H.; Wu, Z. G.; Huang, G.; Peng, N. F.; Huang, R.; Mao, W. X.; Peng, S.; Chen, Y. Q.; Zhu, Y.;Tian, T.*; Zhang, X. L. *; Zhou, X. *, A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C target.Science Advances2016,2(4), e1501535. (Science子刊)
4.Tian, T.#; Chen, Y.#; Wang, S.*; Zhou, X.*, G-Quadruplex: A Regulator of Gene Expression and Its Chemical Targeting.Chem 2018,4, 1314-1344. (Cell子刊)
5. Wang, S. R.#; Zhang, Q. Y.#; Wang, J. Q.#; Ge, X. Y.; Song, Y. Y.; Wang, Y. F.; Li, X. D.; Fu, B. S.; Xu, G. H.; Shu, B.; Gong, P.; Zhang, B. *;Tian, T.*; Zhou, X. *, Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene.Cell Chemical Biology2016,23(9), 1113-22. (Cell子刊)
6. Wang, S.#; Song, Y.#; Wei, L.; Liu, C.; Fu, B.; Wang, J.; Yang, X.; Liu, Y.; Liu, S.;Tian, T.*; Zhou, X.*, Cucurbit[7]uril-Driven Host-Guest Chemistry for Reversible Intervention of 5-Formylcytosine-Targeted Biochemical Reactions.Journal of the American Chemical Society2017,139(46), 16903-12.
7.Tian, T.#; Song, Y.#; Wang, J.; Fu, B.; He, Z.; Xu, X.; Li, A.; Zhou, X.; Wang, S. *; Zhou, X. *, Small-Molecule-Triggered and Light-Controlled Reversible Regulation of Enzymatic Activity.Journal of the American Chemical Society2016,138(3), 955-61.
8. Wang, S.; Long, Y.; Wang, J.; Ge, Y.; Guo, P.; Liu, Y.;Tian, T.*; Zhou, X. *, Systematic investigations of different cytosine modifications on CpG dinucleotide sequences: the effects on the B-Z transition.Journal of the American Chemical Society2014,136(1), 56-9.
9.Tian, T.#; Song, Y.#; Wei, L.#; Wang, J.; Fu, B.; He, Z.; Yang, X. R.; Wu, F.; Xu, G.; Liu, S. M.; Li, C.; Wang, S. *; Zhou, X. *, Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host-guest interactions.Nucleic Acids Research2017,45(5), 2283-2293.
10. Wang, S.#; Song, Y.#; Wang, Y.; Li, X.; Fu, B.; Liu, Y.; Wang, J.; Wei, L.;Tian, T.*; Zhou, X. *, The m6A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide.Chemical Science2017,8(9), 6380-6388.
