个人简介

武汉大学化学与分子科学学院教授，博士生导师；主要从事生物传感分析、核酸纳米技术、生物医学材料等研究。致力于开发新型分析检测方法与探针、开发先进纳米技术与材料、建立智能医学诊疗材料与方法。截至目前，在相关领域国际权威学术期刊发表论文180余篇（包括90余篇通讯作者论文和20篇一作论文），一作及通讯作者论文包括1篇Chem. Rev.，1篇Chem. Soc. Rev.，1篇Acc. Chem. Res.，6篇J. Am. Chem. Soc.，12篇Angew. Chem.，1篇Nat. Commun.，1篇Nucleic Acids Res.，2篇Adv. Mater.，1篇Adv. Sci.，12篇Chem. Sci.，16篇Anal. Chem.，2篇Adv. Func. Mater.，3篇ACS Nano，2篇Nano lett.，9篇Small，3篇CCS Chem.，1篇Matter等，H因子58。获批中、美专利5项，参编关于核酸纳米技术书目章节4个。获选武汉大学蓝月亮奖教金，获评湖北省化学化工青年奖。

教育经历

1999.09-2003.06     郑州大学化学系       大学本科

2003.09-2009.01     中国科学院长春应化所   博士研究生

工作经历

2009.02-014.06      希伯来大学化学系    博士后

2008.07-至今         武汉大学化学与分子科学学院    教授

研究方向

生物分析与传感、核酸化学生物学、核酸纳米技术

代表成果

1. Shizhen He, Jinhua Shang, Yuqiu He, Fuan Wang*, Enzyme-free Dynamic DNA Reaction Networks for On-Demand Bioanalysis and Bioimaging. Acc. Chem. Res., 2024, 57, 533. (Cover Paper)

2. Yuqiu He, Qing Wang, Chen Hong, Ruomeng Li, Jinhua Shang, Shanshan Yu, Xiaoqing Liu, Fuan Wang*, A Smart Deoxyribozyme-Programmable Catalytic DNA Logic Circuit for High-Contrast MicroRNA Imaging. Angew. Chem. Int. Ed., 2023, 62, e202307418.

3 Ruomeng Li, Yuxuan Zhu, Xue Gong, Yanping Zhang, Chen Hong, Yeqing Wan, Xiaoqing Liu, Fuan Wang*, Self-Stacking Autocatalytic Molecular Circuit with Minimal Catalytic DNA Assembly. J. Am. Chem. Soc., 2023, 145, 2999.

4. Shizhen He, Shanshan Yu, Ruomeng Li, Yingying Chen, Qing Wang, Yuqiu He, Xiaoqing Liu, Fuan Wang*, On-Site Nonenzymatic Orthogonal Activation of a Catalytic DNA Circuit for Self-Reinforced In Vivo MicroRNA Imaging. Angew. Chem. Int. Ed., 2022, 61, e202206529. (VIP PAPER)

5. Huimin Wang, Yuqiu He, Jie Wei, Hong Wang, Kang Ma, Yangjie Zhou, Xiaoqing Liu, Xiang Zhou, Fuan Wang*, Construction of an Autocatalytic Hybridization Assembly Circuit for Amplified In Vivo MicroRNA Imaging. Angew. Chem. Int. Ed., 2022, 61, e202115489. (HOT PAPER)

6. Qing Wang, Kaiyue Tan, Hong Wang, Jinhua Shang, Yeqing Wan, Xiaoqing Liu, Xiaocheng Weng, Fuan Wang*, Orthogonal Demethylase-Activated Deoxyribozyme for Intracellular Imaging and Gene Regulation. J. Am. Chem. Soc., 2021, 143, 6895.

7. Jing Wang, Shanshan Yu, Qiong Wu, Xue Gong, Shizhen He, Jinhua Shang, Xiaoqing Liu, Fuan Wang*, A Self-Catabolic Multifunctional DNAzyme Nanosponge for Programmable Drug Delivery and Efficient Gene Silencing. Angew. Chem. Int. Ed., 2021, 60, 10766.

8. Jie Wei, Huimin Wang, Qiong Wu, Xue Gong, Kang Ma, Xiaoqing Liu and Fuan Wang*, A Smart Autocatalytic DNAzyme Biocircuit for in vivo MRI-Guided MicroRNA Imaging. Angew. Chem. Int. Ed., 2020, 59, 5965. (HIGHLY CITED PAPER, HOT PAPER)

9. Xue Gong, Ruomeng Li, Jing Wang, Jie Wei, Kang Ma, Xiaoqing Liu, Fuan Wang*, A Smart Theranostic Nanocapsule for Spatiotemporally Programmable Photo-Genetherapy. Angew. Chem. Int. Ed., 2020, 59, 21648.

10. Huimin Wang, Yuqi Chen, Hong Wang, Xiaoqing Liu, Xiang Zhou, Fuan Wang*, DNAzyme-Loading MOFs for Self-Sufficient Gene Therapy. Angew. Chem. Int. Ed., 2019, 58, 7380. (HIGHLY CITED PAPER)