个人简介
武汉大学化学与分子科学学院教授，博士生导师；2012年入选武汉市“黄鹤英才计划”；2013年入选“教育部新世纪优秀人才计划”；2015年获聘武汉大学珞珈特聘教授；2022年获聘武汉大学-中南医院交叉研究院特聘教授。已发表学术论文110余篇，获授权发明专利3项；获2005年湖北省自然科学一等奖1项（排名第2）、教育部2012年度“高等学校十大科技进展”1项（排名第3）。”现担任Bioactive Carbohydrates and Dietary Fibre期刊编委 (2015-现在)。近5年主持国家自然科学基金3项、国家重点研发计划子课题1项。
教育经历
1997年6月,毕业于武汉大学化学系获理学学士学位
2000年5月,赴日本大阪大学从事高分子溶液理论研究一年
2002年6月,毕业于武汉大学化学与分子科学学院获理学博士学位
工作经历
2001年7月,入职于武汉大学化学与分子科学学院从事高分子教学和科研
2008年10月,获日本学术振兴学会（JSPS）资助赴神户大学从事多糖的结构-活性相关性研究二年
研究方向
天然高分子
1、多糖的多尺度结构、溶液性质及品质功能
2、多糖基微纳米材料
3、多糖的生物活性、构效关系及作用机制
代表成果
1. Liqin Cai†, Shujun Zhou†, Xiaojuan Xu*, Yanfeng Wang*, Zongwei Cai*, Lina Zhang. The composites of triple-helix glucan nanotubes/selenium nanoparticles target hepatocellular carcinoma to enhance ferroptosis by depleting glutathione and augmenting redox imbalance. Chem. Eng. J. 2022, 446(3): 137110.
2. Liqin Cai, Lina Zhang, Xiaojuan Xu*. One-step synthesis of ultra-small silver nanoparticles-loaded triple-helix β-glucan nanocomposite for highly catalytic hydrogenation of 4-nitrophenol and dyes. Chem. Eng. J. 2022, 442(1): 136114.
3. Huanhuan Chen#, Ying Sun#, Xiaojuan Xu*, Qifa Ye*. Targeted delivery of methotrexate by modified yeast β-glucan nanoparticles for rheumatoid arthritis therapy. Carbohydr. Polym. 2022, 284: 119183.
4. Bingchao Duan, Ying Sun, Siwei Zou, Xiaojuan Xu*. Fabrication of tumor-targeting composites based on the triple helical a-glucan through conjugation of aptamer. Carbohydr. Polym. 2021, 254: 117476.
5. Ying Sun, Bingchao Duan, Huanhuan Chen, Xiaojuan Xu*. A novel strategy for treating inflammatory bowel disease by targeting delivery of methotrexate through glucan particles. Adv. Healthcare Mater. 2020, 9 (6): 1901805.
6. Siwei Zou, Bingchao Duan, Xiaojuan Xu*. Inhibition of tumor growth by b-glucans through promoting CD4+ T cell immunomodulation and neutrophil-killing in mice. Carbohydr. Polym. 2019, 213: 370-381. 25.
7. Bingchao Duan#, Mengxia Li#, Ying Sun, Siwei Zou, Xiaojuan Xu*. Orally delivered antisense oligodeoxyribonucleotides of TNF-a via polysaccharide-based nanocomposites targeting intestinal inflammation. Adv. Healthcare Mater. 2019, 8(5): 1801389.
8. Bingchao Duan, Ying Sun, Siwei Zou, Xiaojuan Xu*. Nanoplatform constructed from a β-glucan and polydeoxyadenylic acid for cancer chemotherapy and imaging. Biomacromolecules 2019, 20 (4): 1567–1577.
9. Yan Meng, Xiaodan Shi, Liqin Cai, Sihai Zhang, Kan Ding, Shaoping Nie, Chuanfu Luo*, Xiaojuan Xu*, Lina Zhang*. Triple helix conformation of a polysaccharide determined with light scattering, AFM and molecular dynamic simulation. Macromolecules 2018, 51 (24): 10150
10. Zhaohua Ping, Ting Liu, Hui Xu, Yan Meng, Wenhua Li, Xiaojuan Xu*, Lina Zhang*. Construction of highly stable selenium nanoparticles embedded in hollow nanofibers of polysaccharide and their antitumor activities. Nano Res. 2017, 10: 3775–3789.
