师资队伍

  • 两院院士
  • 高层次人才
  • 在职教师
  • 荣休教师

周强辉

办公地点:

联系电话:027-68755487

电子邮箱:qhzhou@@whu.edu.cn

团队主页:qhzhou.whu.edu.cn

个人简介

教育经历

2001.9—2005.7 学士

北京大学化学与分子科学学院

导师:李维红教授和吴谨光教授

2005.9—2010.7 博士(有机化学)

中科院上海有机化学研究所,生命有机国家重点实验室

导师:马大为研究员

2010.7—2011.7 助理研究员

中科院上海有机化学研究所,生命有机国家重点实验室

合作导师:马大为研究员

2011.8—2015.5 研究助理

The Scripps Research Institute, Chemistry Department, La Jolla, CA

合作导师:Phil S. Baran教授

2015.6— 教授、博导

武汉大学化学与分子科学学院,有机化学研究所

2015.8— 研究员(兼职)

武汉大学高等研究院

工作经历

研究方向

“天然产物合成实验室”研究方向为稀缺活性天然产物的高效全合成,以及相关的合成方法学、化学生物学和药物化学研究。旨在为具有重要价值的稀缺活性天然产物量身打造新颖的合成方法学,在此基础上发展高效、实用的全合成路线,为进一步的化学生物学和药物化学研究奠定坚实的物质基础。具体分为四个研究方向:

1.新颖合成方法学和合成策略的发展

2.活性天然产物的高效、实用全合成路线开发

3.重要活性天然产物、药物分子及其类似物的化学生物学和药物化学研究

4.重要药物分子的新工艺开发

周老师组建的武汉大学“天然产物合成研究室”成立于2015年6月,实验室位于化院北楼110-116房间。欢迎有志于有机合成研究的青年才俊前来交流、切磋和学习;欢迎参加武汉大学“优秀大学生暑期夏令营”的同学参观 “天然产物合成研究室”;欢迎优秀学子报考“天然产物合成研究室”的推免研究生和博士研究生。

此外,因研究工作需要,“天然产物合成研究室”长期招募优秀的博士后研究员(年薪20-30万)和研究助理,享受武汉大学相关福利政策,待遇非常优厚,欢迎来信垂询。

代表成果

30. Ze-Shui Liu, Yu Hua,# Qianwen Gao,# Yuanyuan Ma, Hua Tang, Yong Shang, Hong-Gang Cheng,Qianghui Zhou*. “Construction of Axial Chirality via Palladium/Chiral Norbornene Cooperative Catalysis”Nature Catalysis2020,accepted.

29. Ze-Shui Liu, Hong-Gang Cheng, Qianghui Zhou*. “Precise Functionalization of Remote C-H Bonds”.Chemical Research in Chinese Universities2020, DOI: 10.1007/s40242-020-0158-3.

28.Qianwen Gao, Ze-Shui Liu, Yu Hua, Siwei Zhou, Hong-Gang Cheng∗,Qianghui Zhou∗. “Alkyl Tosylates as Alkylating Reagents in the Catellani Reaction”Synthesis2020, 52, 834−846.

27. Chenggui Wu,Hong-Gang Cheng, Wei Yan,Qianghui Zhou*. (2019), “Epoxide as a Dual-functionalized Alkylating Reagent in Catellani Reactions for the Assembly of Heterocycles”Synlett,2020, 31, 829−837. (Invited Contribution).

26. Chenggui Wu, Xinjun Yang, Yong Shang, Hong-Gang Cheng, Wei Yan,Qianghui Zhou* “Synthesis of Benzofused Dioxabicycle Scaffolds via a Catellani Strategy”Org. Lett.2019, 21: 8938−8942.

25. Qianwen Gao, Yong Shang, Fuzhen Song, Jinxiang Ye, ZeShui Liu, Lisha Li, Hong-Gang Cheng,Qianghui Zhou*. “A Modular Dual-Tasked C-H Methylation via the Catellani Strategy”J. Am. Chem. Soc,2019, DOI: 10.1021/jacs.9b07857.

24.Shijun Gao, Guangyin Qian, Hao Tang, Zuo Yang,Qianghui Zhou*. “Three-Step Total Synthesis of Ramelteon via a Catellani Strategy”ChemCatChem,2019, DOI: 10.1002/cctc.201901355. (Invited contribution for Themed Issue)

23. Shuqing Chen, Peng Wang, Hong-Gang Cheng, Chihui Yang,Qianghui Zhou*. “Redox-Neutral Ortho-C‒H Amination of Pinacol Arylborates via Palladium(II)/Norbornene Catalysis for Anilines Synthesis”,Chem. Sci.,2019, 10, 8384−8389.

22. Junlin Wang, Yanan Zhang, Huanhuan Liu, Yong Shang, Linjun Zhou, Penglin Wei, Wen-Bing Yin, Zixin Deng, Xudong Qu*,Qianghui Zhou*. “A Biocatalytic Hydroxylation Enabled Unified Approach to C19-H hydroxylated Steroids”,Nature Commun.,2019,DOI: 10.1038/s41467-019-11344-0..

21. Qianwen Gao, Ze-Shui Liu, Yu Hua, Lisha Li, Hong-Gang Cheng, Hengjiang Cong,Qianghui Zhou*. “A Palladium/Norbornene Cooperative Catalysis to Access NContaining Bridged Scaffolds”,Chem. Comm.,2019, 55, 8816−8819.(Themed issue: 2019 Emerging Investigators)

20. Pang Wang, Shuqing Chen, Zhiyu Zhou, Hong-Gang Cheng,Qianghui Zhou*. “Chemoselective Borono-Catellani Arylation for Unsymmetrical Biaryls Synthesis”,Org. Lett.,2019, 21,3323−3327.

19. Ze-Shui Liu, Guangyin Qian, Qianwen Gao, Peng Wang, Hong-Gang Cheng, Yu Hua,Qianghui Zhou*, “5-Norbornene-2-carboxylic acid: Another catalytic mediator for Catellani-type reactions”Tetrahedron,2019,75, 1774–1780. (In Honor of Late Prof. Wei-Shan Zhou)

18. Hong-Gang Cheng, Shuqing Chen, Ruiming Chen, andQianghui Zhou*, “The Pd(II)-Initiated Catellani-type Reactions”,Angew. Chem. Int. Ed.2019,58, 5832–5844 (Minireview) (Invited Contribution)

17. Hong-Gang Cheng andQianghui Zhou*, “Bridgehead-Modified NBEs: A Solution to ortho-Constraint in Catellani-type Reactions”Chem,2018, 4, 1775–1777. (Preview)

16. Ze-Shui Liu,# Qianwen Gao,# Hong-Gang Cheng*, andQianghui Zhou*. “The Alkylating Reagents Employed in Catellani-Type Reactions”,Chem. Eur. J.2018,24,15461–15476.(Selected as Inside Cover). (Invited Contribution)

15. Guangyin Qian, Miao Bai, Shijun Gao, Han Chen, Siwei Zhou, Hong-Gang Cheng*, Wei Yan andQianghui Zhou*. “Modular One-Step Three-Component Synthesis of Tetrahydroisoquinolines via a Catellani Strategy”,Angew. Chem. Int. Ed.2018,57, 10980 –10984. (Highlighted bySynfact2018‚ 1128)

14. Chenggui Wu, Hong-Gang Cheng,* Ruiming Chen,# Han Chen,# Ze-Shui Liu, Jingyang Zhang, Yuming Zhang, Yuxin Zhu, Zhi Geng, andQianghui Zhou*. “Convergent Syntheses of 2,3-Dihydrobenzofurans via a Catellani Strategy”,Org. Chem. Front.2018,5, 2533-2536. (Selected as Front Cover). (#: co-first authors)

13. Shuqing Chen#, Ze-Shui Liu#, Tao Yang, Yu Hua, Zhiyu Zhou, Hong-Gang Cheng andQianghui Zhou*. “The Discovery of A Pd(II)-Initiated Borono-Catellani Reaction”,Angew. Chem. Int. Ed.2018,57, 7161-7165. (#: co-first authors) (Highlighted bySynfact2018‚ 856)

12. Zeshui Liu#, Guangyin Qian#, Qianwen Gao, Peng Wang, Hong-Gang Cheng, Qiang Wei, Qi Liu, andQianghui Zhou*, “A Palladium/Norbornene Cooperative Catalysis to Access Tetrahdronaphthalenes and Indanes with a Quaternary Center”,ACS Catal.2018,8, 4783-4788. (#: co-first authors)

11. Yin Zhao, Xiaomeng Wang, Qingqing Wang,Qianghui Zhou, and Bo Zhong*et al. “USP2a Supports Metastasis by Tuning TGF-β Signaling”,Cell Reports2018,22, 2442–2454.

10. Hong-Gang Cheng, Chenggui Wu, Han Chen#, Ruiming Chen#, Guangyin Qian, Zhi Geng, Qiang Wei,Yuanyuan Xia, Jingyang Zhang, Yuming Zhang andQianghui Zhou*, “Epoxides as Alkylating Reagents for the Catellani Reaction”,Angew. Chem. Int. Ed.2018,57, 3444-3448. (Selected as Front Cover, Highly Cited Papers)

9. Hong-Gang Cheng,# Han Chen,# Yue Liu, andQianghui Zhou*, “The Liebeskind–Srogl Cross-Coupling Reaction and its Synthetic Applications”,Asian J. Org. Chem.2018,7, 490-508. (#: co-first authors) (Invited Contribution)

8. Ying Hu,# Miao Bai,# Ying Yang# andQianghui Zhou*, “Metal-Catalyzed Enyne Cycloisomerization in Natural Product Total Synthesis”,Org. Chem. Front.2017, 4, 2256-2275. (#: co-first authors) (Invited Contribution)

7. Hans Renata#,Qianghui Zhou#, Georg Dünstl, Jakob Felding, Rohan R. Merchant, Chien-Hung Yeh and Phil S. Baran*. “Development of a Concise Synthesis of Ouabagenin and Hydroxylated Corticosteroid Analogs”,J. Am. Chem. Soc.2015, 137, 1330-1340. (#: co-first authors)

6. Jinghan Gui#,Qianghui Zhou#, Chung-Mao Pan, Yuki Yabe, Aaron C. Burns, Michael R. Collins, Martha A. Ornelas, Yoshihiro Ishihara and Phil S. Baran*. “A C–H Methylation of Heteroarenes Inspired by Radical SAM Methyl Transferase”,J. Am. Chem. Soc.2014,136,4853-4856. (Selected as Editor’s Choice) (#: co-first authors)

5. Qianghui Zhou, Jinghan Gui, Chung-Mao Pan, Earl Albone, Xin Cheng, Edward M. Suh, Luigi Grasso, Yoshihiro Ishihara, Phil S. Baran*. “Bioconjugation by Native Chemical Tagging of C–H Bonds”,J. Am. Chem. Soc.2013,135, 12994-12997.

4. Qianghui Zhou, Alessandro Ruffoni, Ryan Gianatassio1, Yuta Fujiwara, Eran Sella, Doran Shabat, Phil S. Baran*. “Direct Synthesis of Fluorinated Heteroarylether Bioisosteres”,Angew. Chem. Int. Ed.2013,52, 3949-3952. (Selected as VIP)

3. Hans Renata,Qianghui Zhou, and Phil S. Baran*. “Strategic Redox Relay Enables A Scalable Synthesis of Ouabagenin, A Bioactive Cardenolide”,Science,2013,339, 59-63.

2. Darryl D. Dixon, Jonathan W. Lockner,Qianghui Zhou, and Phil S. Baran*, “Scalable, Divergent Synthesis of Meroterpenoidsvia“Borono-sclareolide””,J. Am. Chem. Soc.2012,134, 8432–8435.

1. Qianghui Zhou, X. Chen, D. Ma*. “Asymmetric, Protecting-Group-Free Total Synthesis of (-)-Englerin A”,Angew. Chem. Int. Ed.,2010,49, 3513-3516.


Patent:

  1. D. Ma, S. Zhu, S. Yu, Y. Wang,Q. Zhou, “Intermediate Compounds of Tamiflu, Methods of Preparation and Uses Thereof”, WO/2011/076086.

  2. M. L. Sierra, J. Felding,Q. Zhou, H. Renata, P. S. Baran, “C-19 Hydroxy pregnenes”, US 2016/0009751A1.

  3. 周强辉、吴承贵、程鸿刚,“一种合成2, 3-二氢苯并呋喃类化合物的方法”,专利号:ZL 201810299042.8.(已授权)

  4. 周强辉、钱光印、白淼,“一种1,2,3,4-四氢异喹啉衍生物的制备方法”,专利号:ZL 201810659587.5.(已授权)

  5. 周强辉、翟旭东、王军林、张亚楠,“19羟基克托多松衍生物及19-羟基雄烯二酮的制备方法”,专利号:ZL201910517841.2.(已授权)

  6. 周强辉、刘泽水、钱光印,“一种具有苄位季碳中心的苯并环衍生物及氢溴酸依他佐辛的制备方法”,申请号:2018102990220.

  7. 瞿旭东,周强辉,张亚楠,王军林,“一种用于系列甾类化合物19位羟化的生物转化方法”,申请号:201910152033.0

  8. 周强辉、陈树清、王鹏,“一种芳香胺类化合物及EphB4激酶抑制剂及其衍生物的制备方法” 申请号:201910610239.3.

  9. 周强辉、高倩文,“一种芳烃甲基化的制备方法” 申请号:201910695981.9.

  10. 周强辉、高仕君、钱光印,“雷美替胺的合成方法” 申请号:201910759938.4.