个人简介
武汉大学化学与分子科学学院副教授，博士生导师
围绕着修饰核酸，包括表观遗传学修饰以及人工修饰的核酸，在核酸的测序、检测、调控方面取得了一些成果，开发出针对特定修饰碱基的测序方法，发现了一些比较好的检测方法和调控手段，下一步我们希望在现有基础上利用这些研究方法和手段，能够在基因层面上对相关的生物功能和机理的研究取得一些突破，并真正将检测技术应用于临床疾病的早期检测和诊断。承担项目与课题1. 国家自然科学基金面上项目(2023)，基于邻近诱导化学的表观遗传修饰核酸结合蛋白的标记方法；2. 国家自然科学基金重点项目(2021) G-四链核酸的分子识别机制与功能的研究。3. 国家自然科学基金面上项目(2016)， DNA中甲基、羟甲基、醛基胞嘧啶多位点检测及胞嘧啶羟甲基修饰的方法研究；4. 国家自然科学基金青年基金(2014)，新型可诱导DNA甲基转移酶和组蛋白甲基转移酶抑制剂的设计合成,构效关系和活性研究。
教育经历
2000.09-2004.06 武汉大学化学与分子科学学院 大学本科
2004.09-2010.07 武汉大学化学与分子科学学院 博士研究生
2007.09-2008.09 格勒诺布尔一大化学系 联合培养研究生
工作经历
2009.01-2010.01 弗吉尼亚大学化学系 访问学者
2013.04-至今 武汉大学化学与分子科学学院 副教授
研究方向
开发修饰碱基测序方法、小分子探针的开发、核酸表观遗传修饰的检测
代表成果
[1] Zhaoxin Chen, Hanfei Zhang, Feng Xiao, Shen Yan, Linao Ren, Song-Mei Liu, Xiaocheng Weng, Xiang Zhou*, Yuhao Du*, Anal Chem. 2024, 96, 13103-13109
[2] Shen Yan, Ziang Lu, Wei Yang, Jinglei Xu, Yafen Wang, Wei Xiong, Rongjie Zhu, Linao Ren, Zhaoxin Chen, Qi Wei, Song-mei Liu, Tian Feng, Bifeng Yuan, Xiaocheng Weng, Yuhao Du*, Xiang Zhou*, Antibody-Free Fluorine-Assisted Metabolic Sequencing of RNA N4-Acetylcytidine. J Am Chem Soc. 2023, 145, 22232-22242..
[3] Zhang Y.; Yan S.; Chen Z.; Jiang X.; Rao S.; Jiang Z.; Qin S.; Zhou X. *; Du Y. *; Visually Intracellular Detection of Telomerase Activity Based on DNA Strand Displacement Reaction and Gold Nanoparticle Labeling, Chin. J. Chem, 2022, 40: 693-698
[4] Yajun Zhang; Qiuyang Zhang; Xiaocheng Weng; Yuhao Du*; Xiang Zhou*; NEase-based amplificat ion for detection of miRNA, multiple miRNAs and circRNA, Analytica Chimica Acta, 2021, 1145: 52-5 8
[5] Yaqian Liu, Xiong Zhang, Min Liu, Fa Xu, Qiuyang Zhang, Yajun Zhang, Xiaocheng Weng, Songmei Liu, Yuhao Du*, Xiang Zhou, Direct detection of circRNA in real samples using reverse transcription-rolling circle amplification, Anal. Chim. Acta., 2020, 1101: 169-175,
[6] Min Liu, Wu Fan, Yuhao Du*, Xiang Zhou*, Specific stabilization of DNA G-quadruplex structures with a chemically modified complementary probe，Bioorg. Med. Chem. 2019, 27, 1962
[7] Yinong Liu, Cheng Zhong, Zhiyong He, Shuang Rao, Haomiao Su, Fan Wu, Boshi Fu, Jinjun Wu, Yanyan Song, Yuhao Du*, and Xiang Zhou* . Sensors and Actuators B, 2018, 255, 2151
[8] Zhiyong He, Chen, Yuqi Chen, Yafen Wang, Jiaqi Wang, Jing Mo, Boshi Fu, Zijing Wang, Xiang Zhou*, Yuhao Du*, A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing, Chem. Commun, 2016, 52, 8545.
[9] Shuang Rao, Yuqi Chen, Tingting Hong, Zhiyong He, Shan Guo, Han Lai, Ge Guo, Yuhao Du*，Xiang Zhou*，Simultaneous and Sensitive Detection of Multisite 5-Methylcytosine Including Non-CpG Sites at Single-5mC-Resolution. Anal. Chem, 2016, 88, 10547.
[10] Yuhao Du*, Xiang Zhou*, Targeting non-B-form DNA in living cells. Chem. Rec, 2013, 371.
[11] Yuhao Du, Charles Hendrick, Krysta Frye, Lindsay Comstock*, Fluorescent DNA labeling by N-mustard analogues of S-adenosyl-L-methionine. ChemBioChem, 2012, 13, 2225.
[12] Mark Turlington, Yuhao Du, Samuel G Ostrum, Wren Vishaka, Tony Lin, Michal Sabat，Lin Pu*, From highly enantioselective catalytic reaction of 1,3-diynes with aldehydes to facile asymmetric synthesis of polycyclic compounds. J. Am. Chem. Soc., 2011, 133, 11780。
[13] Yuhao Du, , Xiaocheng Weng, Jing Huang, Dan Zhang, Heng Ma, Dong Chen, Xiang Zhou*, Constant, Jean-Francois, Oligonucleotide-selenide conjugate: synthesis and its inducible sequence-specific alkylation of DNA. Bioorg. Med. Chem. 2010, 18, 4149.
[14] Yuhao Du, Mark Turlington, Xiang Zhou, Lin Pu*, Highly enantioselective addition of linear alkyl alkynes to linear aldehydes. Tetrahedron Lett., 2010, 51, 5024. (IF: 2.259, 三区)
[15] Yuhao Du, Dan Zhang, Wei Chen, Ming Zhang, Yangyang Zhou, Xiang Zhou*, Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition. Bioorg. Med. Chem. 2010, 18, 1111.
[16] Yuhao Du, Jing Huang, Xiaocheng Weng, Xiang Zhou*, Specific Recognition of DNA by Small Molecules. Curr. Med. Chem. 2010, 17, 173.
