师资队伍

  • 两院院士
  • 高层次人才
  • 在职教师
  • 荣休教师

刘晓庆

办公地点:

联系电话:13618660366

电子邮箱:xiaoqingliu@whu.edu.cn

团队主页:

个人简介

刘晓庆,山东人,曾获中科院刘永龄特等奖,入选国家级人才项目。

研究兴趣包括分析化学方法、生物医学材料等。主要围绕核酸分子的组装与调控,开发先进材料与探针,用于传感分析检测、精准诊疗研究。相关成果发表在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nat. Commun., ACS Nano, Nano Lett., Acc. Chem. Res., Adv. Mater., Adv. Funct. Mater., Biomaterials, Chem. Sci., Anal. Chem.等国际一流期刊100余篇并被广泛引用,授权专利6项。ORCID:https://orcid.org/0000-0002-1309-5454


教育经历

2009年初于中科院长春应用化学研究所电分析化学国家重点实验室获博士学位


工作经历

2009至2015年,先后在丹麦奥胡斯大学化学系、交叉学科纳米中心,以色列耶路撒冷希伯来大学化学研究所、纳米科学与技术中心工作。

2015年,加入武汉大学化学与分子科学学院,任教授、博士生导师。


研究方向

研究兴趣包括分析化学方法、生物医学材料等。主要围绕核酸分子的组装与调控,开发先进材料与探针,用于传感分析检测、精准诊疗研究。


代表成果

(1)A Dynamic DNA Nanosponge for TriggeredAmplification of Gene-Photodynamic Modulation.Chem. Sci.,2022,https://doi.org/10.1039/D2SC00459C

(2)Boosting Cancer Immunotherapy Via the Convenient A2AR Inhibition Using a Tunable Nanocatalyst with Light-Enhanced Activity.Adv. Mater., 2022, 34, 2106967. https://doi.org/10.1002/adma.202106967

(3)Multifunctional DNAzyme-Anchored Metal–Organic Frameworks for Efficient Suppression of Tumor Metastasis.ACS Nano,2022, 16(4), 5404-5417.https://doi.org/10.1021/acsnano.1c09008

(4) Visualization of Vaccine Dynamics with Quantum Dots for Immunotherapy.Angew. Chem. Int. Ed., 2021, 60(45), 24275-24283.https://doi.org/10.1002/anie.202111093

(5) Precision Spherical Nucleic Acids Enable Sensitive FEN1 Imaging and Controllable Drug Delivery for Cancer Specific Therapy.Anal. Chem.,2021, 93(32), 11275–11283.https://doi.org/10.1021/acs.analchem.1c02264

(6)A Cooperatively Activatable DNA Nanoprobe for Cancer Cell-Selective Imaging of ATP.Anal. Chem., 2021, 93(41), 13960–13966.https://doi.org/10.1021/acs.analchem.1c03284

(7) A smart multiantenna gene theranostic system based on the programmed assembly of hypoxia-related siRNAs.Nat. Commun.,2021,12, 3953.https://doi.org/10.1038/s41467-021-24191-9

(8)A Bionanozyme with Ultrahigh Activity Enables Spatiotemporally Controlled Reactive Oxygen Species Generation for Cancer Therapy.Adv. Funct. Mater., 2021,31, 2104100.https://doi.org/10.1002/adfm.202104100

(9)Precision Photothermal Therapy and Photoacoustic Imaging by In Situ Activatable Thermoplasmonics.Chem. Sci.,2021,12, 10097-10105.https://doi.org/10.1039/D1SC02203B

(10)Regulation of Redox Balance Enhances Phototherapy Efficacy and Suppresses Tumor Metastasis Using a Biocompatible Nanoplatform,Chem. Sci.,2021,12, 148-157.https://doi.org/10.1039/D0SC04983B(Highlighted as Outside Front Cover)

(11)Portable and sensitive detection of non-glucose target by enzyme-encapsulated metal-organic-framework using personal glucose meter.Biosens. Bioelectron., 2022, 198, 113819.

(12) Bio-Inspired Dynamic Biomolecule Assembling for Fine Regulation of Protein Activity.Chem. Commun., 2021,57, 11205-11208.https://doi.org/10.1039/D1CC03926A

(13) Modulation of Oxidative Stress in Cancer Cells with A Biomineralized Converter.ACS Materials Lett., 2021,3, 1778-1785.https://doi.org/10.1021/acsmaterialslett.1c00470

(14)An efficient photochemotherapy nanoplatform based on the endogenous biosynthesis of photosensitizer in macrophage-derived extracellular vesicles,Biomaterials,2021,279, 121234.https://doi.org/10.1016/j.biomaterials.2021.121234

(15) A mitochondrial oxidative stress amplifier to overcome hypoxia resistance for enhanced photodynamic therapy.Small Methods, 2021, 5(9), 2100581.https://doi.org/10.1002/smtd.202100581

(16) In situ generated and amplified oxidative stress with metallo-nanodrug assembly for metastatic cancer therapy with high specificity and efficacy.Adv. Therap., 2021,https://doi.org/10.1002/adtp.202100148

(17) Multiple Blockades of the HGF/Met Signaling Pathway for Metastasis Suppression Using Nanoinhibitors.ACS Appl. Mater. Inter.,2021, 13(26), 30350–30358. https://doi.org/10.1021/acsami.1c07010

(18) Cascaded Amplifier Nanoreactor for Efficient Photodynamic Therapy.ACS Appl. Mater. Inter.,2021, 13(14), 16075–16083.https://doi.org/10.1021/acsami.1c01683

(19) Programming DNA Nanoassembly for Enhanced Photodynamic Therapy,Angew. Chem. Int. Ed., 2020, 59(5), 1897-1905.https://doi.org/10.1002/anie.201915591(Highlighted as Front Cover)

(20) Biosynthesized Quantum Dot for Facile and Ultrasensitive Electrochemical and Electrochemiluminescence Immunoassay,Anal. Chem.,2020, 92(1), 1598-1604.https://doi.org/10.1021/acs.analchem.9b04919

(21) Immunostimulatory DNA Nanogel Enables Effective Lymphatic Drainage and High Vaccine Efficacy,ACS Materials Lett., 2020, 2(12), 1606–1614.https://pubs.acs.org/doi/10.1021/acsmaterialslett.0c00445(Highlighted as Supplementary Cover)

(22)Enhanced Immunostimulatory Activity of a Cytosine-Phosphate-Guanosine Immunomodulator by the Assembly of Polymer DNA Wires and Spheres,ACS Appl. Mater. Inter.,2020, 12(15), 17167-17176.https://doi.org/10.1021/acsami.9b21075

(23) Quantum Dot-Pulsed Dendritic Cell Vaccines Plus Macrophage Polarization for Amplified Cancer Immunotherapy,Biomaterials,2020, 242, 119928.https://doi.org/10.1016/j.biomaterials.2020.119928

(24)Treating Immunologically Cold Tumors by Precise Cancer Photoimmunotherapy with an Extendable Nanoplatform,ACS Appl. Mater. Inter.,2020, 12(36), 40002–40012.https://doi.org/10.1021/acsami.0c09469

(25)Effective Nanotherapeutic Approach for Metastatic Breast Cancer Treatment by Supplemental Oxygenation and Imaging-Guided Phototherapy,Nano Research,2020, 13, 1111-1121.https://doi.org/10.1007/s12274-020-2753-5

(26)Plasmonic and Photothermal Immunoassay via Enzyme-Triggered Crystal Growth on Gold Nanostars,Anal. Chem.,2019, 91(3), 2086–2092.https://doi.org/10.1021/acs.analchem.8b04517

(27)Versatile Catalytic Deoxyribozyme Vehicles for Multimodal Imaging-Guided Efficient Gene Regulation and Photothermal Therapy,ACS Nano,2018, 12 (12), 12888–12901.https://doi.org/10.1021/acsnano.8b08101

(28) DNA Switches: From Principles to Applications.Angew. Chem. Int. Ed.2015, 54,1098–1129.https://doi.org/10.1002/anie.201404652

(29) Switchable reconfiguration of nucleic acid nanostructures by stimuli-responsive DNA machines.Acc. Chem. Res.2014,47, 1673–1680.https://doi.org/10.1021/ar400316h

(30) Dual Switchable CRET-Induced Luminescence of CdSe/ZnS Quantum Dots (QDs) by the Hemin/G-Quadruplex-Bridged Aggregation and Deaggregation of Two-Sized QDs.Nano Lett.2014, 14, 6030-6035.https://doi.org/10.1021/nl503299f

(31) Graphene Oxide/Nucleic Acid-Stabilized Silver Nanoclusters: Functional Hybrid Materials for Optical Aptamer Sensing and Multiplexed Analysis of Pathogenic DNAs.J. Am. Chem. Soc.2013,135, 11832–11839.https://doi.org/10.1021/ja403485r

(32) Probing Biocatalytic Transformations with Luminescent DNA/Ag Nanoclusters.Nano Lett.2013,13, 309–314.https://doi.org/10.1021/nl304283c

(33) Switching Photonic and Electrochemical Functions of a DNAzyme by DNA Machines.Nano Lett.2013,13, 219–225.https://doi.org/10.1021/nl303894h

(34) Multiplexed Aptasensors and Amplified DNA Sensors Using Functionalized Graphene Oxide: Application for Logic Gate Operations.ACS Nano2012, 6, 3553–3563.https://doi.org/10.1021/nn300598q

(35) Chemiluminescent and Chemiluminescence Resonance Energy Transfer (CRET) Detection of DNA, Metal Ions, and Aptamer-Substrate Complexes Using Hemin/G-Quadruplexes and CdSe/ZnS Quantum Dots.J. Am. Chem. Soc.2011,133, 11597–11604.https://doi.org/10.1021/ja202639m

(37)Chemiluminescence and Chemiluminescence Resonance Energy Transfer (CRET) Aptamer Sensors Using Catalytic Hemin/G-Quadruplexes.ACS Nano2011,5, 7648–7655.https://doi.org/10.1021/nn202799d

(38) Environmentally Friendly and Highly Sensitive Ruthenium(II) Tris(2,2'-bipyridyl) Electrochemiluminescent System Using 2-(dibutylamino)ethanol as Co-Reactant.Angew. Chem. Int. Ed.2007,46, 421–424. DOI:10.1002/anie.200603491(VIP, Very Important Paper)

专利:

(1)发明人:李景虹,王美佳,刘晓庆,专利名称:脱氧核糖核酸电化学纳米传感器的制备方法,专利号: 03127158.8,公开号:CN1525163,授权公告日:2005.08.17

(2)发明人:徐国宝,刘晓庆,史立红,专利名称:环境友好的高灵敏电化学发光检测方法,专利号:200510016848.4,公开号: CN1696666,授权公告日:2010.01.27

(3)发明人:徐国宝,史立红,刘晓庆,牛文新,专利名称:三联吡啶钌电化学发光测定血浆钙的方法,专利号: 200510017231.4,公开号:CN1773259,授权公告日: 2009.05.20

(4)发明人:徐国宝,史立红,刘晓庆,李海娟,专利名称:溶胶-凝胶法制备的碳陶瓷材料的应用,专利号: 200510017012.6,公开号:CN1736581,授权公告日:2007.10.10

(5)发明人:徐国宝,史立红,刘晓庆,专利名称:Nafion-碳陶瓷复合材料电化学发光传感器的制备方法,专利号:CN200510016770.6, 公开号: CN1693285,授权公告日:2007.05.09

(6)Itamar Willner, Fuan Wang, Chun-Hua Lu, Xiaoqing Liu, Lina Freage, Compositions, kits, uses and methods for amplified detection of an analyte, United States Patent 9809846, Application Number:14/586214, Publication Date: 11/07/2017, Filing Date: 12/30/2014