个人简介

武汉大学化学与分子科学学院教授、博士生导师，中国化学会高级会员、中国光学学会高级会员，首届中国分析测试协会优秀青年奖获得者（2004年）。主持完成国家和省部级科研项目20余项（其中主持国家自然科学基金项目8项）。1999-2002年曾协助主持国家九五科学仪器攻关项目“阿达玛变换显微图像分析仪”。 2019-2023主持国家重大科研仪器研制项目“用于活细胞内单颗粒示踪和实时操纵的光镊显微镜”。 发表SCI论文130多篇，引用三千余次。

教育经历

1987.09-1991.06 武汉大学化学系 大学本科

1991.09-1994.07 武汉大学化学系 硕士研究生

1994.09-1997.06 武汉大学化学与分子科学学院 博士研究生

工作经历

1997.07-1998.11 华侨大学应用化学系 讲师

1998.12-2000.05 武汉大学化学与分子科学学院 讲师

2000.06-2009.11 武汉大学化学与分子科学学院 副教授

2005.11-2006.11 英国利兹大学物理与天文学院 访问学者

2014.03-2014.08 丹麦哥本哈根大学Niels Bohr研究所 高级研究学者

2009.12-至今 武汉大学化学与分子科学学院 教授

研究方向

生物光子学检测技术及仪器、纳米材料与纳米生物传感

代表成果

1.Yuyao Li, Haodong Li, Yawen Zheng, Dadi Xu, Liu Liu, Ao Liu, Tianning Li, Daiwen Pang, Hongwu Tang*. Optical tweezer-driven mechanotransduction: probing pN-scale forces and calcium-mediated redox signaling in single endothelial cells. ACS Nano, 2025, 19: 16084−16095.

2. Dadi Xu, Liu Liu, Yawen Zheng, Yuyao Li, Pengfei Xu, Yang Liu, Hongwu Tang*. Optical trapping of a single virus in a host cell based on active-passive calibration for trap stiffness. ACS Nano, 2025, 19: 20144−20152.

3. He Yu, Peng-Fei Xu, Yang Liu, Zeng-Shuai Jia, Yu-Yao Li, Hong-Wu Tang*. LRET-based simultaneous detection of dual miRNAs via multi-trap optical tweezers assisted suspension array tagged by two different luminescence quenchable UCNPs combining CRISPR/Cas12a amplification. Analytical Chemistry, 2025, 97: 602 −612.

4. Yawen Zheng, Jiangtao Li, Dadi Xu, Liu Liu, Yuyao Li, Jing Yi, Jiayao Dong, Daiwen Pang, Hongwu Tang*. Tunneling nanotubes mediate KRas transport: inducing tumor heterogeneity and altering cellular membrane mechanical properties. Acta Biomaterialia, 2024, 185: 312–322.

5. Dadi Xu, Jiangtao Li, Liu Liu, Hongwu Tang*. Boosting the optical trapping of a single virus by quantum dots tagging increases virus polarizability and trap stiffness. ACS Applied Materials & Interfaces, 2023, 15: 55174 −55182.

6. He Yu, Zeng-Shuai Jia, Peng-Fei Xu, Yang Liu, Da-Di Xu, Yu-Yao Li, Hong-Wu Tang*. Multiple miRNA detection through a suspended microbead array encoded by triple-color upconversion luminescent nanotags via bi-beam splitter hybrid-multitrap optical tweezers. Analytical Chemistry, 2023, 95(37): 14086–14093.

7. Wen-Kai Fang, Da-Di Xu, Da Liu, Yu-Yao Li, Meng-Han Liu, Dai-Wen Pang, Hong-Wu Tang*. Combining upconversion luminescence, photothermy and electrochemistry for highly accurate triple-signal detection of hydrogen sulphide by optically trapping single microbeads. Analytical Chemistry, 2023, 95(12): 5443–5453.

8. Wen-Kai Fang, Liu Liu, Li-ling Zhang, Da Liu, Yang Liu, Hong-Wu Tang*. Detection of amyloid β oligomers by a fluorescence ratio strategy based on optically trapped highly doped upconversion nanoparticles-SiO2@metal–organic framework microspheres. Analytical Chemistry, 2021, 93(36): 12447–12455.

9. Cheng-Yu Li, Bei Zheng, Jiang-Tao Li, Jia-ling Gao, Yu-Heng Liu, Dai-Wen Pang, Hong-Wu Tang*. Holographic optical tweezers and boosting upconversion luminescent resonance energy transfer combined clustered regularly interspaced short palindromic repeats (CRISPR)/Cas12a biosensors. ACS Nano, 2021, 15: 8142−8154.

10.Li Xia, Li-Juan Zhang, Hong-Wu Tang*, Dai-Wen Pang. Revealing microtubule-dependent slow-directed motility by single particle tracking. Analytical Chemistry, 2021, 93(12): 5211–5217.

11. Bei Zheng, Ya-Feng Kang, Ting Zhang, Cheng-Yu Li, Sha Huang, Zhi-Ling Zhang, Qiong-Shui Wu, Chu-Bo Qi, Dai-Wen Pang, Hong-Wu Tang*. Breaking through flow bead assay: combination of near-infrared optical tweezers stabilizing and upconversion luminescence encoding. Analytical Chemistry, 2020, 92(7): 5258-5266.

12.Ya-Feng Kang, Bei Zheng, Chengyu Li, Zhi-Ling Zhang, Hong-Wu Tang*, Qiongshui Wu, Dai-Wen Pang. Real-time monitoring of temperature variations around a gold nanobipyramid targeted cancer cell under photothermal heating by actively manipulating an optically trapped luminescent upconversion microparticle. Analytical Chemistry, 2020, 92(1): 1292−1300.

13. Cheng-Yu Li, Ya-Feng Kang, Chu-Bo Qi, Bei Zheng, Ming-Qiu Zheng, Chong-Yang Song, Zhen-Zhong Guo, Yi Lin, Dai-Wen Pang, Hong-Wu Tang*. Breaking through bead-supported assay: Integration of optical tweezers assisted fluorescence imaging and luminescence confined upconversion nanoparticles triggered luminescent resonance energy transfer (LRET). Analytical Chemistry, 2019, 91(12): 7950-7957.

14. Cheng-Yu Li, Di Cao, Chu-Bo Qi, Ya-Feng Kang, Chong-Yang Song, Dang-Dang Xu, Bei Zheng, Dai-Wen Pang, Hong-Wu Tang*. Combining holographic optical tweezers with upconversion luminescence encoding: Imaging-based stable suspension array for sensitive responding of dual cancer biomarkers. Analytical Chemistry, 2018, 90(4): 2639-2647.

15. Cheng-Yu Li, Di Cao, Ya-Feng kang, Yi Lin, Ran Cui, Dai-Wen Pang, Hong-Wu Tang*. Fluorescence detection of H5N1 virus gene sequences based on optical tweezers with two-photon excitation using a single near infrared nanosecond pulse laser. Analytical Chemistry, 2016, 88: 4432−4439.

16. Li Cai, Ze-Zhong Chen, Min-Yan Chen, Hong-Wu Tang*, Dai-Wen Pang. MUC-1 aptamer-conjugated dye-doped silica nanoparticles for MCF-7 cells detection. Biomaterials, 2013, 34: 371-381.

17. Yue He, Ling-Hong Xiong, Xiao-Jing Xing, Hong-Wu Tang*, Dai-Wen Pang. An ultra-high sensitive platform for fluorescence detection of micrococcal nuclease based on graphene oxide. Biosensors and Bioelectronics, 2013, 42: 467-473.

18. Yue He, Yi Lin, Hong-Wu Tang*, Dai-Wen Pang. A graphene oxide-based fluorescent aptasensor for the turn-on detection of epithelial tumor marker mucin 1. Nanoscale, 2012, 4: 2054–2059.

19. Xiao-Jing Xing, Xue-Guo Liu, Yue-He, Qing-Ying Luo, Hong-Wu Tang*, Dai-Wen Pang. Graphene oxide based fluorescent aptasensor for adenosine deaminase detection using adenosine as the substrate. Biosensors & Bioelectronics, 2012, 37: 61–67.

20. Hong-Wu Tang*, Xuebin B. Yang, Jennifer Kirkham, D. Alastair Smith. Probing intrinsic and extrinsic components in single osteosarcoma cells by near-infrared surface-enhanced Raman scattering. Analytical Chemistry, 2007, 79(10): 3646–3653.