师资队伍

  • 两院院士
  • 高层次人才
  • 在职教师
  • 荣休教师

程巳雪

办公地点:

联系电话:68754061

电子邮箱:chengsixue@whu.edu.cn

团队主页:

个人简介

武汉大学教师个人主页系统 程巳雪 首页 中文主页 (whu.edu.cn)


教育经历

学士:华南理工大学1992年

硕士:中国科学技术大学1995年

博士:新加坡国立大学2000年


工作经历

2000年1月-2001年1月: 新加坡材料研究与工程研究所(研究助理)

2001年1月-2003年11月:武汉大学化学学院生物医用高分子材料教育部重点实验室(副教授)

2003年11月-至今:   武汉大学化学学院生物医用高分子材料教育部重点实验室(教授)


研究方向

生物医用高分子

药物及基因传递材料

生物材料的自组装


代表成果

(由于网络设置等原因,论文清单的格式被自动修改,如一些应有的空格被自动删除,特此说明。)

1.Xu C, He XY, Ren XH, Han D,Cheng SX*, Detection of mRNAs of ribosomal protein L15 and E-cadherin in living circulating tumor cells at single cell resolution to study tumor heterogeneity,Anal. Chem. 2022, 94, 10610−10616.

2.Ren XH, He XY, Xu C, Han D,Cheng SX*,Functional tumor targeting nano-systems for reprogramming circulating tumor cells with in situ evaluation on therapeutic efficiency at the single-cell level, Adv. Sci. 2022, 2105806.

3.Han D, Xu C, Ren XH, Peng Y, Xu B, Song JL, Chen J,Cheng SX*, In situ detection on nanotoxicity in living cells based on multiple miRNAs probed by peptide functionalized nanoprobe,Anal. Chem. 2022, 94, 2399−2407.

4.Ren XH, Xu C, Li LL, Zuo Y, Han D, He XY*,Cheng SX*, A targeting delivery system for effective genome editing in leukemia cells to reverse malignancy, J. Control. Release 2022,343, 645–656.

5.Xu C, He XY, Ren XH,Cheng SX*, Direct detection of intracellular miRNA in living circulating tumor cells by tumor targeting nanoprobe in peripheral blood,Biosen. Bioelectron. 2021, 190, 113401.

6.Ai SL, Wang CX, Peng Y, Tu Y, Lei JJ, Xu C, Ren XH,Cheng SX*, An albumin-based therapeutic nanosystem for photosensitizer/protein co-delivery to realize synergistic cancer therapy, ACS Appl. Bio Mater. 2021, 4, 4946−4952.

7.He XY, Ren XH, Peng Y, Zhang JP, Ai SL, Liu BY, Xu C,Cheng SX*, Aptamer/peptide functionalized genome editing system for effective immune restoration through reversal of PD-L1 mediated cancer immunosuppression, Adv. Mater. 2020, 32, 2000208.

8.Xu C, He XY, Peng Y, Dai BS, Liu BY,Cheng SX*, Facile strategy to enhance specificity and sensitivity of molecular beacons by an aptamer-functionalized delivery vector, Anal. Chem. 2020, 92, 2088-2096.

9.Ren XH, He XY, Liu BY, Xu C,Cheng SX*, Self-assembled plasmid delivery system for PPM1D knockout to reverse tumor malignancy, ACS Appl. Bio Mater. 2020, 3, 7831-7839.

10.He XY, Liu BY, Peng Y, Zhuo RX,Cheng SX*, Multifunctional vector for delivery of genome editing plasmid targeting β‑catenin to remodulate cancer cell properties, ACS Appl. Mater. Interfaces 2019, 11, 226-237.

11.Liu BY, He XY, Xu C, Ren XH, Zhuo RX,Cheng SX*, Peptide and aptamer decorated delivery system for targeting delivery of Cas9/sgRNA plasmid to mediate anti-tumor genome editing, ACS Appl. Mater. Interfaces 2019, 11, 23870-23879.

12.Ai SL, He XY, Liu BY, Zhuo RX,Cheng SX*, Targeting delivery of oligodeoxynucleotides to macrophages by mannosylated cationic albumin for immune stimulation in cancer treatment, Mol. Pharm. 2019, 16, 2616-2625.

13.Xu L, Wang SB, Xu C, Han D, Ren XH, Zhang XZ,Cheng SX*,Multifunctional albumin-based delivery system generated by programmed assembly for tumor-targeted multimodal therapy and imaging, ACS Appl. Mater. Interfaces 2019, 11, 38385-38394.

14.Liu BY, He XY, Zhuo RX,Cheng SX*, Reversal of tumor malignization and modulation of cell behaviors through genome editing mediated by a multi-functional nanovector, Nanoscale 2018, 10, 21209-21218.

15.Liu BY, He XY, Zhuo RX,Cheng SX*, Tumor targeted genome editing mediated by a multi-functional gene vectorfor regulating cell behaviors,J. Control. Release 2018, 291, 90-98.

16.He XY, Liu BY, Xu C, Zhuo RX,Cheng SX*, A multi-functional macrophage and tumor targeting gene delivery system for regulation of macrophage polarity and reversal of cancer immunoresistance, Nanoscale2018, 10, 15578-15587.

17.Liu BY, He XY, Xu C, Xu L, Ai SL,Cheng SX*, Zhuo RX*, A dual-targeting delivery system for effective genome editing and in situ detecting related protein expression in edited cells, Biomacromolecules 2018, 19, 2957-2968.

18.Xu L, He XY, Liu BY, Xu C, Ai SL, Zhuo RX,Cheng SX*, Aptamer-functionalized albumin-based nanoparticles for targeted drug delivery,Colloids Surf. B Biointerf.2018, 171, 24-30.