师资队伍

  • 两院院士
  • 高层次人才
  • 在职教师
  • 荣休教师

张先正

办公地点:

联系电话:

电子邮箱:xz-zhang@whu.edu.cn

团队主页:

个人简介

现任武汉大学研究生院副院长兼培养教育处处长,生物医用高分子材料教育部重点实验室主任。入选国家级人才计划特聘教授、国家杰出青年基金获得者、 “万人计划”科技创新领军人才、享受国务院政府特殊津贴、国际生物材料科学与工程学会联合会Fellow、英国皇家化学学会Fellow、中国生物材料学会青年科学家奖获得者、科技部中青年科技创新领军人才、教育部新世纪优秀人才计划、湖北省优秀科技工作者、湖北青年五四奖章金奖、湖北省青年科技奖获得者。


教育经历

1994年于武汉大学获学士学位,1997年于武汉大学获硕士学位,2000年于武汉大学获博士学位。


工作经历

2000年9月至2001年8月  新加坡材料研究所(IMRE)  Research Associate。

2001年9月至2004年9月  美国康奈尔大学(Cornell University)  博士后。

自2004年9月起在武汉大学化学与分子科学学院高分子系任教授,博士生导师。


研究方向

研究领域为生物医用高分子。针对恶性肿瘤等重大疾病诊疗的难点,在生物医用高分子领域开展了系统、深入的研究。围绕高分子载体高效负载、智能响应及功能协同的科学问题,提出了“肿瘤触发靶向”、“信封型”功能协同、“活性生物材料”等新方法、新策略,精准、高效地将药物传递到肿瘤组织,显著提高疗效、降低药物毒副作用,以及克服肿瘤的多药耐药性等。已在Chem. Soc. Rev.、Prog. Mater. Sci.、Prog. Polym. Sci.、Nat. Biomed. Eng.、Sci. Adv.、Nat. Commun.、Adv. Mater.、JACS、Angew. Chem. Int. Ed.、Nano Lett.、ACS Nano、Adv. Func. Mater.、Biomaterials等期刊发表SCI论文560多篇,SCI他引29000多次,H因子90。2015年以来连续入选中国高被引学者榜单(材料科学)。参编学术专著4部。申报国内外专利20多项,部分专利已转让。 研究成果获教育部自然科学奖一等奖1项、二等奖1项、湖北省自然科学奖一等奖1项。Materials Today Chemistry 创刊主编、Materials Today、Regen. Biomater.、中国科学-化学、高分子学报、化学学报、功能高分子、高分子材料科学与工程、胶体与聚合物等国内外期刊编委等。


代表成果

1.Liu LH, Zhang XZ.* Carrier-free nanomedicines for cancer treatment. Prog. Mater. Sci. 2022, 125, 100919. (Review)

2.Chen QW, Qiao JY, Liu XH, Zhang C, Zhang XZ.* Customized m aterials-assisted microorganisms in tumor therapeutics. Chem. Soc. Rew. 2021, 50, 12576-12615. (Review)

3.Luo GF, Chen WH, Zeng X, Zhang XZ.* Cell primitives-based biomimetic functional materials: a promising biocompatible formulation for enhanced cancer therapy. Chem. Soc. Rev. 2021, 50, 945-985. (Review)

4.Hu JJ, Lei Q, Zhang XZ.* Recent advances in photonanomedicines for breaking the “Logjam” of cancer photodynamic therapy. Prog. Mater. Sci. 2020, 114, 100685. (Review)

5.Zheng DW, Deng WW, Song WF, Wu CC, Liu J, Hong S, Zhuang ZN, Cheng H, Sun ZJ,* Zhang XZ.* Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma. Nat. Biomed. Eng. 2022, 6, 32-43.

6.Zheng DW, Pan P, Chen KW, Fan JX, Li CX, Deng RH, Cheng H, Zhang XZ.* An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure. Nat. Biomed. Eng. 2020, 4, 853-862.

7.Zheng DW, Dong X, Pan P, Chen KW, Fan JX, Cheng SX, Zhang XZ.* Phage-guided modulation of the gut microbiota of mouse models of colorectal cancer augments their responses to chemotherapy. Nat. Biomed. Eng. 2019, 3, 717-728.

8.Zeng JY, Wang XS, Xie BR, Li QR, Zhang XZ.* Large π-conjugated metal-organic frameworks for infrared-light-driven CO2 reduction. J. Am. Chem. Soc. 2022, 144, 1218-1231.

9.Zhang QL, Zheng DW, Dong X, Pan P, Zeng SM, Gao F, Zeng X, Zhang XZ.* A biomimetic peptide stimulates natural antigen-presenting system and boosts cancer immunotherapy. J. Am. Chem. Soc. 2021, 143, 5127-5140.

10.Li ZH, Chen Y, Zeng X, Zhang XZ.* A mesoporous silica-based nanoplatform depletes cysteine to improve oxytosis of tumor. Nano Today 2021, 38, 101150.

11.Dong X, Pan P, Zheng DW, Bao P, Zeng X, Zhang XZ.* Bio-inorganic hybrid bacteriophage for modulation of intestinal microbiota to remodel tumor-immune microenvironment against colorectal cancer. Sci. Adv. 2020, 6, eaba1590.

12.Zheng DW, Gao F, Cheng Q, Bao P, Dong X, Fan JX, Song W, Zeng X, Cheng SX, Zhang XZ.* A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy. Nat. Commun. 2020, 11, 1985.

13.Li RQ, Zheng DW, Han ZY, Xie TQ, Zhang C, An JX, Xu R, Sun YX, Zhang XZ.* mHealth: a smartphone-controlled, wearable platform for tumour treatment. Mater. Today 2020, 40, 91-100.

14.Li B, Ji P, Peng SY, Pan P, Zheng DW, Li CX, Sun YX, Zhang XZ.* Nitric oxide release device for remote-controlled cancer therapy by wireless charging. Adv. Mater. 2020, 32, 2000376.

15.Zeng JY, Wang XS, Xie BR, Li MJ, Zhang XZ.* Covalent organic framework for improving near‐infrared light induced fluorescence imaging through two-photon induction. Angew. Chem. Int. Ed. 2020, 59, 10087-1009.

16.Liu WL, Zou MZ, Liu T, Zeng JY, Li X, Yu WY, Li CX, Ye JJ, Song W, Feng J*, Zhang XZ.* Cytomembrane nanovaccines by mimicking tumor cells and antigen presenting cells. Nat. Commun. 2019, 10, 3199.

17.Zeng JY, Wang XS, Qi YD, Yu Y, Zeng X, Zhang XZ.* Structural transformation in metal-organic framework for reversible binding of oxygen. Angew. Chem. Int. Ed. 2019, 58, 5692-5696

18.Fan JX, Peng MY, Wang H, Zheng HR, Liu ZL, Li CX, Wang XN, Liu XH, Cheng SX, Zhang XZ.* Engineered bacterial bioreactor for tumor therapy via fenton-like reaction with localized H2O2 generation. Adv. Mater. 2019, 31, 1808278

19.Zheng DW, Fan JX, Liu XH, Dong X, Pan P, Xu L, Zhang XZ.* A simply modified lymphocyte for systematic cancer therapy. Adv. Mater. 2018, 30, 1801622.

20.Wang XG, Cheng Q, Yu Y, Zhang XZ.* A general and scalable strategy for size precisely controlled synthesis of nanoscale metal-organic frameworks. Angew. Chem. Int. Ed. 2018, 57, 7836-7840.