个人简介

武汉大学化学与分子科学学院副教授，围绕生物医用材料在疾病诊断、治疗中的应用，发展了系列新型生物功能材料。在Advanced Materials, Nature Communications, Biomaterials等国际顶级刊物共发表SCI论文47篇，主持和参与国家自然科学基金项目7项，企业横向项目1项。研究方向为生物医用高分子材料的设计及其应用研究，包括药物控释，基因传递，分子影像等，近年来在肿瘤诊疗材料的研究领域做了大量系统性的研究工作，取得了不少具有创新性的成果。

教育经历

1999.09-2003.06    湖北大学化学系   大学本科

2003.09-2008.12    武汉大学化学与分子科学学院   博士研究生

工作经历

2009.07-2021.11  武汉大学化学与分子科学学院   讲师

2016.10-2017.09  凯斯西储大学生物工程学院       访问学者

2021.11-至今       武汉大学化学与分子科学学院   副教授

研究方向

药物控释，基因传递系统、肿瘤诊疗材料

代表成果

1.Dong, CY; Huang, QX; Cheng, H*; Zheng, DW; Hong, S; Yan, Y; Niu, MT; Xu, JG*; Zhang, XZ*, Neisseria meningitidis Opca Protein/MnO2 Hybrid Nanoparticles for Overcoming the Blood-Brain Barrier to Treat Glioblastoma, Adv. Mater., 2022,34,12:2109213

2.Wang, XG; Cheng, H*; Zhang, XZ, Flexible-on-rigid heteroepitaxial metal-organic frameworks induced by template lattice change, Nano Res., 2022,15,5:4693-4699

3.Yu, Y; Xie, BR; Liu, XH; Ye, JJ; Cheng, H*; Zhong, ZL*; Zhang, XZ*, A H2O2-responsive theranostic platform for chemiluminescence detection and synergistic therapy of tumors, J. Mat. Chem. B, 2021,12:5629

4.Zheng, DW; Pan, P; Chen, KW; Fan, JX; Li, CX; Cheng, H; Zhang, XZ*, An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure, Nat. Biomed. Eng, 2020,4,9:853

5.Wan, SS; Liu, MD; Cheng, Q; Cheng, H*; Zhang, XZ*, A Mitochondria-Driven Metabolic Sensing Nanosystem for Oxygen Availability and Energy Blockade of Cancer, Adv. Therap., 2020,3,6:2000019

6.Chen, ZX; Liu, MD; Guo, DK; Zou, MZ; Wang, SB; Cheng, H*; Zhong, ZL; Zhang, XZ*, A MSN-based tumor-targeted nanoplatform to interfere with lactate metabolism to induce tumor cell acidosis for tumor suppression and anti-metastasis, Nanoscale, 2020,12,5:2966-2972

7.Peng, MY; Wang, XQ; Zhang, Y; Li, CX; Zhang, MK; Cheng, H*; Zhang, XZ*, Mitochondria-Targeting Thermosensitive Initiator with Enhanced Anticancer Efficiency, ACS Appl. Bio Mater., 2019,2,10:4656-4666

8.Zhang, AN; Wu, W; Zhang, C; Wang, QY; Zhuang, ZN; Cheng, H*; Zhang, XZ*, A versatile bacterial membrane-binding chimeric peptide with enhanced photodynamic antimicrobial activity, J. Mat. Chem. B, 2019,7,7:1087-1095

9.Li, RQ; Zhang, C; Xie, BR; Yu, WY; Qiu, WX; Cheng, H*; Zhang, XZ*, A two-photon excited O-2-evolving nanocomposite for efficient photodynamic therapy against hypoxic tumor, Biomaterials, 2019,194:84-93

10.Wan, SS; Zeng, JY; Cheng, H*; Zhang, XZ*, ROS-induced NO generation for gas therapy and sensitizing photodynamic therapy of tumor, Biomaterials, 2018,185:51-62