个人简介
武汉大学化学与分子科学学院副教授,围绕生物医用材料在疾病诊断、治疗中的应用,发展了系列新型生物功能材料。在Advanced Materials, Nature Communications, Biomaterials等国际顶级刊物共发表SCI论文47篇,主持和参与国家自然科学基金项目7项,企业横向项目1项。研究方向为生物医用高分子材料的设计及其应用研究,包括药物控释,基因传递,分子影像等,近年来在肿瘤诊疗材料的研究领域做了大量系统性的研究工作,取得了不少具有创新性的成果。
教育经历
1999.09-2003.06 湖北大学化学系 大学本科
2003.09-2008.12 武汉大学化学与分子科学学院 博士研究生
工作经历
2009.07-2021.11 武汉大学化学与分子科学学院 讲师
2016.10-2017.09 凯斯西储大学生物工程学院 访问学者
2021.11-至今 武汉大学化学与分子科学学院 副教授
研究方向
药物控释,基因传递系统、肿瘤诊疗材料
代表成果
1.Dong, CY; Huang, QX; Cheng, H*; Zheng, DW; Hong, S; Yan, Y; Niu, MT; Xu, JG*; Zhang, XZ*, Neisseria meningitidis Opca Protein/MnO2 Hybrid Nanoparticles for Overcoming the Blood-Brain Barrier to Treat Glioblastoma, Adv. Mater., 2022,34,12:2109213
2.Wang, XG; Cheng, H*; Zhang, XZ, Flexible-on-rigid heteroepitaxial metal-organic frameworks induced by template lattice change, Nano Res., 2022,15,5:4693-4699
3.Yu, Y; Xie, BR; Liu, XH; Ye, JJ; Cheng, H*; Zhong, ZL*; Zhang, XZ*, A H2O2-responsive theranostic platform for chemiluminescence detection and synergistic therapy of tumors, J. Mat. Chem. B, 2021,12:5629
4.Zheng, DW; Pan, P; Chen, KW; Fan, JX; Li, CX; Cheng, H; Zhang, XZ*, An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure, Nat. Biomed. Eng, 2020,4,9:853
5.Wan, SS; Liu, MD; Cheng, Q; Cheng, H*; Zhang, XZ*, A Mitochondria-Driven Metabolic Sensing Nanosystem for Oxygen Availability and Energy Blockade of Cancer, Adv. Therap., 2020,3,6:2000019
6.Chen, ZX; Liu, MD; Guo, DK; Zou, MZ; Wang, SB; Cheng, H*; Zhong, ZL; Zhang, XZ*, A MSN-based tumor-targeted nanoplatform to interfere with lactate metabolism to induce tumor cell acidosis for tumor suppression and anti-metastasis, Nanoscale, 2020,12,5:2966-2972
7.Peng, MY; Wang, XQ; Zhang, Y; Li, CX; Zhang, MK; Cheng, H*; Zhang, XZ*, Mitochondria-Targeting Thermosensitive Initiator with Enhanced Anticancer Efficiency, ACS Appl. Bio Mater., 2019,2,10:4656-4666
8.Zhang, AN; Wu, W; Zhang, C; Wang, QY; Zhuang, ZN; Cheng, H*; Zhang, XZ*, A versatile bacterial membrane-binding chimeric peptide with enhanced photodynamic antimicrobial activity, J. Mat. Chem. B, 2019,7,7:1087-1095
9.Li, RQ; Zhang, C; Xie, BR; Yu, WY; Qiu, WX; Cheng, H*; Zhang, XZ*, A two-photon excited O-2-evolving nanocomposite for efficient photodynamic therapy against hypoxic tumor, Biomaterials, 2019,194:84-93
10.Wan, SS; Zeng, JY; Cheng, H*; Zhang, XZ*, ROS-induced NO generation for gas therapy and sensitizing photodynamic therapy of tumor, Biomaterials, 2018,185:51-62